novel research: olives and weigh loss
Written on: Setyembre 20, 2017
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Title : novel research: olives and weigh loss
link : novel research: olives and weigh loss
Oleuropein, a natural product derived from olive leaves, has reported anti-diabetic functions. However, detailed molecular mechanisms for how it affects β-cell functions remain poorly understood. Here, we present evidence that oleuropein promotes glucose-stimulated insulin secretion (GSIS) in β-cells. The effect is dose-dependent and stimulates the ERK/MAPK signaling pathway. We further demonstrated that oleuropein inhibits the cytotoxicity induced by amylin amyloids, a hallmark feature of type 2 diabetes. We demonstrated that these dual functions are structure-specific: we identified the 3-hydroxytyrosol moiety of oleuropein as the main functional entity responsible for amyloid inhibition, but the novel GSIS function requires the entire structure scaffold of the molecule.
[full paper is here]
You are now reading the article novel research: olives and weigh loss with link address https://trensnviral.blogspot.com/2017/09/novel-research-olives-and-weigh-loss.html
Title : novel research: olives and weigh loss
link : novel research: olives and weigh loss
novel research: olives and weigh loss
Oleuropein, a natural product derived from olive leaves, has reported anti-diabetic functions. However, detailed molecular mechanisms for how it affects β-cell functions remain poorly understood. Here, we present evidence that oleuropein promotes glucose-stimulated insulin secretion (GSIS) in β-cells. The effect is dose-dependent and stimulates the ERK/MAPK signaling pathway. We further demonstrated that oleuropein inhibits the cytotoxicity induced by amylin amyloids, a hallmark feature of type 2 diabetes. We demonstrated that these dual functions are structure-specific: we identified the 3-hydroxytyrosol moiety of oleuropein as the main functional entity responsible for amyloid inhibition, but the novel GSIS function requires the entire structure scaffold of the molecule.
[full paper is here]
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You are now reading the article novel research: olives and weigh loss with link address https://trensnviral.blogspot.com/2017/09/novel-research-olives-and-weigh-loss.html
