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Title : omega-3 fatty acid supplementation and CVDs : there is no link !
link : omega-3 fatty acid supplementation and CVDs : there is no link !

omega-3 fatty acid supplementation and CVDs : there is no link !

Today, it is crystal clear that omega-3 fatty acids do NOT lower cardiovascular risk!
The rise of doubts of the value of omega-3 fatty acids in relation to cardiovascular diseases started in 2012 with this paper

Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.






In 2013, in this paper
should you still recommend omega-3 supplements?

we read that 

PRACTICE CHANGER

Stop recommending omega-3 fatty acid supplements for cardiovascular protection. They have no significant impact on all-cause mortality, acute myocardial infarction, sudden death, or stroke.¹

In 2014,  the last discussion paragraph of the paper

Omega-3 Supplements and Cardiovascular Diseases

is of some interest

In summary and in light of the current best evidence, we can conclude that omega-3 supplements might possibly confer cardiovascular benefits but their benefits will be minimal, if any. We are also unsure if there is a subset of patients that would benefit most from this supplementation. Further ongoing investigations could be helpful in that regard. And finally, would the current best evidence lend support to widespread use of omega-3 supplements for primary or secondary CVD prevention? Our answer given the existing evidence would be “no”. Why not starting with the well-balanced Mediterranean diet, instead?

Finally, in 2016,
in the paper
Omega-3 polyunsaturated fatty acid supplementation in the prevention of cardiovascular disease

we can read that 

Knowledge into Practice

• Omega-3 polyunsaturated fatty acids (PUFAs) have a variety of purported effects that are thought to lower the risk of cardiovascular disease (CVD).
• Based on clinical trial data, omega-3 PUFA supplements lower serum triglyceride levels but do not affect serum low-density lipoprotein cholesterol levels.
• Multiple large, randomized, placebo-controlled trials have shown no benefit with omega-3 PUFA supplements for the primary prevention of CVD.
• There appears to be no benefit with omega-3 PUFA supplements for the secondary prevention of CVD when added to guideline-based pharmacotherapy in both the early and late period after a myocardial infarction.
• Many pharmacies stock omega-3 PUFA supplements. Therefore, pharmacists are ideally situated to engage patients in a discussion specifically about the lack of CVD benefit with omega-3 PUFAs, as well as the potential adverse effects.
   
  = = =
   
  To conclude, we need to reconsider our practice by taking into account:
  1. the side effects of statins as presented here
   
  
   
   
  2. the cardioprotective effects of food polar lipids as discussed here.
  
  
  Ioannis Zabetakis
  
  

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